RapamycinFungusV1, Main, Exploration, bibRecord, 000822

IL-15 Complexes Induce Migration of Resting Memory CD8 T Cells into Mucosal Tissues.

Identifieur interne : 000822 ( Main/Exploration ); précédent : 000821; suivant : 000823

IL-15 Complexes Induce Migration of Resting Memory CD8 T Cells into Mucosal Tissues.

Auteurs : Ryan T. Sowell [États-Unis] ; Josef W. Goldufsky [États-Unis] ; Magdalena Rogozinska [États-Unis] ; Zurisaday Quiles [États-Unis] ; Yanxia Cao [États-Unis] ; Eliseo F. Castillo [États-Unis] ; Alison Finnegan [États-Unis] ; Amanda L. Marzo [États-Unis]

Source :

Journal of immunology (Baltimore, Md. : 1950) [ 1550-6606 ] ; 2017.

RBID : pubmed:28814601

Descripteurs français

KwdFr :
- Animaux (MeSH), Différenciation cellulaire (effets des médicaments et des substances chimiques), Interleukine-15 (génétique), Interleukine-15 (pharmacologie), Interleukine-15 (physiologie), Lymphocytes T CD8+ (effets des médicaments et des substances chimiques), Lymphocytes T CD8+ (physiologie), Mouvement cellulaire (MeSH), Muqueuse (cytologie), Muqueuse (effets des médicaments et des substances chimiques), Muqueuse (immunologie), Mémoire immunologique (MeSH), Protéine O1 à motif en tête de fourche (métabolisme), Protéines proto-oncogènes c-bcl-6 (génétique), Protéines à domaine boîte-T (génétique), Sirolimus (pharmacologie), Souris (MeSH), Souris de lignée C57BL (MeSH), Sous-populations de lymphocytes T (effets des médicaments et des substances chimiques), Sérine-thréonine kinases TOR (métabolisme), Transduction du signal (effets des médicaments et des substances chimiques).
MESH :
- cytologie : Muqueuse.
- effets des médicaments et des substances chimiques : Différenciation cellulaire, Lymphocytes T CD8+, Muqueuse, Sous-populations de lymphocytes T, Transduction du signal.
- génétique : Interleukine-15, Protéines proto-oncogènes c-bcl-6, Protéines à domaine boîte-T.
- immunologie : Muqueuse.
- métabolisme : Protéine O1 à motif en tête de fourche, Sérine-thréonine kinases TOR.
- pharmacologie : Interleukine-15, Sirolimus.
- physiologie : Interleukine-15, Lymphocytes T CD8+.
- Animaux, Mouvement cellulaire, Mémoire immunologique, Souris, Souris de lignée C57BL.

English descriptors

KwdEn :
- Animals (MeSH), CD8-Positive T-Lymphocytes (drug effects), CD8-Positive T-Lymphocytes (physiology), Cell Differentiation (drug effects), Cell Movement (MeSH), Forkhead Box Protein O1 (metabolism), Immunologic Memory (MeSH), Interleukin-15 (genetics), Interleukin-15 (pharmacology), Interleukin-15 (physiology), Mice (MeSH), Mice, Inbred C57BL (MeSH), Mucous Membrane (cytology), Mucous Membrane (drug effects), Mucous Membrane (immunology), Proto-Oncogene Proteins c-bcl-6 (genetics), Signal Transduction (drug effects), Sirolimus (pharmacology), T-Box Domain Proteins (genetics), T-Lymphocyte Subsets (drug effects), TOR Serine-Threonine Kinases (metabolism).
MESH :
- chemical , genetics : Interleukin-15, Proto-Oncogene Proteins c-bcl-6, T-Box Domain Proteins.
- chemical , metabolism : Forkhead Box Protein O1, TOR Serine-Threonine Kinases.
- cytology : Mucous Membrane.
- drug effects : CD8-Positive T-Lymphocytes, Cell Differentiation, Mucous Membrane, Signal Transduction, T-Lymphocyte Subsets.
- immunology : Mucous Membrane.
- chemical , pharmacology : Interleukin-15, Sirolimus.
- physiology : CD8-Positive T-Lymphocytes, Interleukin-15.
- Animals, Cell Movement, Immunologic Memory, Mice, Mice, Inbred C57BL.

Abstract

IL-15 is an essential cytokine known to promote T cell survival and activate the effector function of memory phenotype CD8 T cells. Blocking IL-15 signals also significantly impacts tissue-specific effector and memory CD8 T cell formation. In this study, we demonstrate that IL-15 influences the generation of memory CD8 T cells by first promoting their accumulation into mucosal tissues and second by sustaining expression of Bcl-6 and T-bet. We show that the mechanism for this recruitment is largely dependent on mammalian target of rapamycin and its subsequent inactivation of FoxO1. Last, we show that IL-15 complexes delivered locally to mucosal tissues without reinfection is an effective strategy to enhance establishment of tissue resident memory CD8 T cells within mucosal tissues. This study provides mechanistic insight into how IL-15 controls the generation of memory CD8 T cells and influences their trafficking and ability to take up residence within peripheral tissues.

DOI: 10.4049/jimmunol.1501638
PubMed: 28814601
PubMed Central: PMC5605445

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000748
to stream Main, to step Curation: 000748

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">IL-15 Complexes Induce Migration of Resting Memory CD8 T Cells into Mucosal Tissues.</title>
<author><name sortKey="Sowell, Ryan T" sort="Sowell, Ryan T" uniqKey="Sowell R" first="Ryan T" last="Sowell">Ryan T. Sowell</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Immunology and Microbiology, Rush University Medical Center, Chicago, IL 60612.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Department of Immunology and Microbiology, Rush University Medical Center, Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Goldufsky, Josef W" sort="Goldufsky, Josef W" uniqKey="Goldufsky J" first="Josef W" last="Goldufsky">Josef W. Goldufsky</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Immunology and Microbiology, Rush University Medical Center, Chicago, IL 60612.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Department of Immunology and Microbiology, Rush University Medical Center, Chicago</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612; and.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Department of Internal Medicine, Rush University Medical Center, Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Rogozinska, Magdalena" sort="Rogozinska, Magdalena" uniqKey="Rogozinska M" first="Magdalena" last="Rogozinska">Magdalena Rogozinska</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612; and.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Department of Internal Medicine, Rush University Medical Center, Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Quiles, Zurisaday" sort="Quiles, Zurisaday" uniqKey="Quiles Z" first="Zurisaday" last="Quiles">Zurisaday Quiles</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612; and.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Department of Internal Medicine, Rush University Medical Center, Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cao, Yanxia" sort="Cao, Yanxia" uniqKey="Cao Y" first="Yanxia" last="Cao">Yanxia Cao</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Immunology and Microbiology, Rush University Medical Center, Chicago, IL 60612.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Department of Immunology and Microbiology, Rush University Medical Center, Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Castillo, Eliseo F" sort="Castillo, Eliseo F" uniqKey="Castillo E" first="Eliseo F" last="Castillo">Eliseo F. Castillo</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Internal Medicine, Clinical Translational Science Center, University of New Mexico School of Medicine, Albuquerque, NM 87131.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Nouveau-Mexique</region>
</placeName>
<wicri:cityArea>Department of Internal Medicine, Clinical Translational Science Center, University of New Mexico School of Medicine, Albuquerque</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Finnegan, Alison" sort="Finnegan, Alison" uniqKey="Finnegan A" first="Alison" last="Finnegan">Alison Finnegan</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Immunology and Microbiology, Rush University Medical Center, Chicago, IL 60612.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Department of Immunology and Microbiology, Rush University Medical Center, Chicago</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612; and.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Department of Internal Medicine, Rush University Medical Center, Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Marzo, Amanda L" sort="Marzo, Amanda L" uniqKey="Marzo A" first="Amanda L" last="Marzo">Amanda L. Marzo</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Immunology and Microbiology, Rush University Medical Center, Chicago, IL 60612; Amanda_Marzo@rush.edu.</nlm:affiliation>
<country wicri:rule="url">États-Unis</country>
<wicri:regionArea>Department of Immunology and Microbiology, Rush University Medical Center, Chicago</wicri:regionArea>
<placeName><settlement type="city">Chicago</settlement>
<region type="state">Illinois</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612; and.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Department of Internal Medicine, Rush University Medical Center, Chicago</wicri:cityArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2017">2017</date>
<idno type="RBID">pubmed:28814601</idno>
<idno type="pmid">28814601</idno>
<idno type="doi">10.4049/jimmunol.1501638</idno>
<idno type="pmc">PMC5605445</idno>
<idno type="wicri:Area/Main/Corpus">000748</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000748</idno>
<idno type="wicri:Area/Main/Curation">000748</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000748</idno>
<idno type="wicri:Area/Main/Exploration">000748</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">IL-15 Complexes Induce Migration of Resting Memory CD8 T Cells into Mucosal Tissues.</title>
<author><name sortKey="Sowell, Ryan T" sort="Sowell, Ryan T" uniqKey="Sowell R" first="Ryan T" last="Sowell">Ryan T. Sowell</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Immunology and Microbiology, Rush University Medical Center, Chicago, IL 60612.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Department of Immunology and Microbiology, Rush University Medical Center, Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Goldufsky, Josef W" sort="Goldufsky, Josef W" uniqKey="Goldufsky J" first="Josef W" last="Goldufsky">Josef W. Goldufsky</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Immunology and Microbiology, Rush University Medical Center, Chicago, IL 60612.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Department of Immunology and Microbiology, Rush University Medical Center, Chicago</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612; and.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Department of Internal Medicine, Rush University Medical Center, Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Rogozinska, Magdalena" sort="Rogozinska, Magdalena" uniqKey="Rogozinska M" first="Magdalena" last="Rogozinska">Magdalena Rogozinska</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612; and.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Department of Internal Medicine, Rush University Medical Center, Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Quiles, Zurisaday" sort="Quiles, Zurisaday" uniqKey="Quiles Z" first="Zurisaday" last="Quiles">Zurisaday Quiles</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612; and.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Department of Internal Medicine, Rush University Medical Center, Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cao, Yanxia" sort="Cao, Yanxia" uniqKey="Cao Y" first="Yanxia" last="Cao">Yanxia Cao</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Immunology and Microbiology, Rush University Medical Center, Chicago, IL 60612.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Department of Immunology and Microbiology, Rush University Medical Center, Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Castillo, Eliseo F" sort="Castillo, Eliseo F" uniqKey="Castillo E" first="Eliseo F" last="Castillo">Eliseo F. Castillo</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Internal Medicine, Clinical Translational Science Center, University of New Mexico School of Medicine, Albuquerque, NM 87131.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Nouveau-Mexique</region>
</placeName>
<wicri:cityArea>Department of Internal Medicine, Clinical Translational Science Center, University of New Mexico School of Medicine, Albuquerque</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Finnegan, Alison" sort="Finnegan, Alison" uniqKey="Finnegan A" first="Alison" last="Finnegan">Alison Finnegan</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Immunology and Microbiology, Rush University Medical Center, Chicago, IL 60612.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Department of Immunology and Microbiology, Rush University Medical Center, Chicago</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612; and.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Department of Internal Medicine, Rush University Medical Center, Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Marzo, Amanda L" sort="Marzo, Amanda L" uniqKey="Marzo A" first="Amanda L" last="Marzo">Amanda L. Marzo</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Immunology and Microbiology, Rush University Medical Center, Chicago, IL 60612; Amanda_Marzo@rush.edu.</nlm:affiliation>
<country wicri:rule="url">États-Unis</country>
<wicri:regionArea>Department of Immunology and Microbiology, Rush University Medical Center, Chicago</wicri:regionArea>
<placeName><settlement type="city">Chicago</settlement>
<region type="state">Illinois</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612; and.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Department of Internal Medicine, Rush University Medical Center, Chicago</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of immunology (Baltimore, Md. : 1950)</title>
<idno type="eISSN">1550-6606</idno>
<imprint><date when="2017" type="published">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term>
<term>CD8-Positive T-Lymphocytes (drug effects)</term>
<term>CD8-Positive T-Lymphocytes (physiology)</term>
<term>Cell Differentiation (drug effects)</term>
<term>Cell Movement (MeSH)</term>
<term>Forkhead Box Protein O1 (metabolism)</term>
<term>Immunologic Memory (MeSH)</term>
<term>Interleukin-15 (genetics)</term>
<term>Interleukin-15 (pharmacology)</term>
<term>Interleukin-15 (physiology)</term>
<term>Mice (MeSH)</term>
<term>Mice, Inbred C57BL (MeSH)</term>
<term>Mucous Membrane (cytology)</term>
<term>Mucous Membrane (drug effects)</term>
<term>Mucous Membrane (immunology)</term>
<term>Proto-Oncogene Proteins c-bcl-6 (genetics)</term>
<term>Signal Transduction (drug effects)</term>
<term>Sirolimus (pharmacology)</term>
<term>T-Box Domain Proteins (genetics)</term>
<term>T-Lymphocyte Subsets (drug effects)</term>
<term>TOR Serine-Threonine Kinases (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term>
<term>Différenciation cellulaire (effets des médicaments et des substances chimiques)</term>
<term>Interleukine-15 (génétique)</term>
<term>Interleukine-15 (pharmacologie)</term>
<term>Interleukine-15 (physiologie)</term>
<term>Lymphocytes T CD8+ (effets des médicaments et des substances chimiques)</term>
<term>Lymphocytes T CD8+ (physiologie)</term>
<term>Mouvement cellulaire (MeSH)</term>
<term>Muqueuse (cytologie)</term>
<term>Muqueuse (effets des médicaments et des substances chimiques)</term>
<term>Muqueuse (immunologie)</term>
<term>Mémoire immunologique (MeSH)</term>
<term>Protéine O1 à motif en tête de fourche (métabolisme)</term>
<term>Protéines proto-oncogènes c-bcl-6 (génétique)</term>
<term>Protéines à domaine boîte-T (génétique)</term>
<term>Sirolimus (pharmacologie)</term>
<term>Souris (MeSH)</term>
<term>Souris de lignée C57BL (MeSH)</term>
<term>Sous-populations de lymphocytes T (effets des médicaments et des substances chimiques)</term>
<term>Sérine-thréonine kinases TOR (métabolisme)</term>
<term>Transduction du signal (effets des médicaments et des substances chimiques)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Interleukin-15</term>
<term>Proto-Oncogene Proteins c-bcl-6</term>
<term>T-Box Domain Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Forkhead Box Protein O1</term>
<term>TOR Serine-Threonine Kinases</term>
</keywords>
<keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Muqueuse</term>
</keywords>
<keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Mucous Membrane</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>CD8-Positive T-Lymphocytes</term>
<term>Cell Differentiation</term>
<term>Mucous Membrane</term>
<term>Signal Transduction</term>
<term>T-Lymphocyte Subsets</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Différenciation cellulaire</term>
<term>Lymphocytes T CD8+</term>
<term>Muqueuse</term>
<term>Sous-populations de lymphocytes T</term>
<term>Transduction du signal</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Interleukine-15</term>
<term>Protéines proto-oncogènes c-bcl-6</term>
<term>Protéines à domaine boîte-T</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Muqueuse</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Mucous Membrane</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Protéine O1 à motif en tête de fourche</term>
<term>Sérine-thréonine kinases TOR</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Interleukine-15</term>
<term>Sirolimus</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Interleukin-15</term>
<term>Sirolimus</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Interleukine-15</term>
<term>Lymphocytes T CD8+</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>CD8-Positive T-Lymphocytes</term>
<term>Interleukin-15</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cell Movement</term>
<term>Immunologic Memory</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Mouvement cellulaire</term>
<term>Mémoire immunologique</term>
<term>Souris</term>
<term>Souris de lignée C57BL</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">IL-15 is an essential cytokine known to promote T cell survival and activate the effector function of memory phenotype CD8 T cells. Blocking IL-15 signals also significantly impacts tissue-specific effector and memory CD8 T cell formation. In this study, we demonstrate that IL-15 influences the generation of memory CD8 T cells by first promoting their accumulation into mucosal tissues and second by sustaining expression of Bcl-6 and T-bet. We show that the mechanism for this recruitment is largely dependent on mammalian target of rapamycin and its subsequent inactivation of FoxO1. Last, we show that IL-15 complexes delivered locally to mucosal tissues without reinfection is an effective strategy to enhance establishment of tissue resident memory CD8 T cells within mucosal tissues. This study provides mechanistic insight into how IL-15 controls the generation of memory CD8 T cells and influences their trafficking and ability to take up residence within peripheral tissues.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28814601</PMID>
<DateCompleted><Year>2017</Year>
<Month>10</Month>
<Day>24</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>11</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1550-6606</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>199</Volume>
<Issue>7</Issue>
<PubDate><Year>2017</Year>
<Month>10</Month>
<Day>01</Day>
</PubDate>
</JournalIssue>
<Title>Journal of immunology (Baltimore, Md. : 1950)</Title>
<ISOAbbreviation>J Immunol</ISOAbbreviation>
</Journal>
<ArticleTitle>IL-15 Complexes Induce Migration of Resting Memory CD8 T Cells into Mucosal Tissues.</ArticleTitle>
<Pagination><MedlinePgn>2536-2546</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.4049/jimmunol.1501638</ELocationID>
<Abstract><AbstractText>IL-15 is an essential cytokine known to promote T cell survival and activate the effector function of memory phenotype CD8 T cells. Blocking IL-15 signals also significantly impacts tissue-specific effector and memory CD8 T cell formation. In this study, we demonstrate that IL-15 influences the generation of memory CD8 T cells by first promoting their accumulation into mucosal tissues and second by sustaining expression of Bcl-6 and T-bet. We show that the mechanism for this recruitment is largely dependent on mammalian target of rapamycin and its subsequent inactivation of FoxO1. Last, we show that IL-15 complexes delivered locally to mucosal tissues without reinfection is an effective strategy to enhance establishment of tissue resident memory CD8 T cells within mucosal tissues. This study provides mechanistic insight into how IL-15 controls the generation of memory CD8 T cells and influences their trafficking and ability to take up residence within peripheral tissues.</AbstractText>
<CopyrightInformation>Copyright © 2017 by The American Association of Immunologists, Inc.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Sowell</LastName>
<ForeName>Ryan T</ForeName>
<Initials>RT</Initials>
<Identifier Source="ORCID">0000-0003-3484-6437</Identifier>
<AffiliationInfo><Affiliation>Department of Immunology and Microbiology, Rush University Medical Center, Chicago, IL 60612.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Goldufsky</LastName>
<ForeName>Josef W</ForeName>
<Initials>JW</Initials>
<Identifier Source="ORCID">0000-0001-5816-6992</Identifier>
<AffiliationInfo><Affiliation>Department of Immunology and Microbiology, Rush University Medical Center, Chicago, IL 60612.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612; and.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rogozinska</LastName>
<ForeName>Magdalena</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612; and.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Quiles</LastName>
<ForeName>Zurisaday</ForeName>
<Initials>Z</Initials>
<AffiliationInfo><Affiliation>Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612; and.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cao</LastName>
<ForeName>Yanxia</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Department of Immunology and Microbiology, Rush University Medical Center, Chicago, IL 60612.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Castillo</LastName>
<ForeName>Eliseo F</ForeName>
<Initials>EF</Initials>
<Identifier Source="ORCID">0000-0002-5083-560X</Identifier>
<AffiliationInfo><Affiliation>Department of Internal Medicine, Clinical Translational Science Center, University of New Mexico School of Medicine, Albuquerque, NM 87131.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Finnegan</LastName>
<ForeName>Alison</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Immunology and Microbiology, Rush University Medical Center, Chicago, IL 60612.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612; and.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Marzo</LastName>
<ForeName>Amanda L</ForeName>
<Initials>AL</Initials>
<AffiliationInfo><Affiliation>Department of Immunology and Microbiology, Rush University Medical Center, Chicago, IL 60612; Amanda_Marzo@rush.edu.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612; and.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>P30 AI082151</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R21 AI095673</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R21 AI121774</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2017</Year>
<Month>08</Month>
<Day>16</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>J Immunol</MedlineTA>
<NlmUniqueID>2985117R</NlmUniqueID>
<ISSNLinking>0022-1767</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C490010">Bcl6 protein, mouse</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000071161">Forkhead Box Protein O1</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C467200">Foxo1 protein, mouse</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D019409">Interleukin-15</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D051560">Proto-Oncogene Proteins c-bcl-6</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D020825">T-Box Domain Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C406820">T-box transcription factor TBX21</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.1.1</RegistryNumber>
<NameOfSubstance UI="D058570">TOR Serine-Threonine Kinases</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.1.1</RegistryNumber>
<NameOfSubstance UI="C546843">mTOR protein, mouse</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>W36ZG6FT64</RegistryNumber>
<NameOfSubstance UI="D020123">Sirolimus</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>AIM</CitationSubset>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018414" MajorTopicYN="N">CD8-Positive T-Lymphocytes</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002454" MajorTopicYN="N">Cell Differentiation</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002465" MajorTopicYN="N">Cell Movement</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000071161" MajorTopicYN="N">Forkhead Box Protein O1</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007156" MajorTopicYN="Y">Immunologic Memory</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019409" MajorTopicYN="N">Interleukin-15</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008810" MajorTopicYN="N">Mice, Inbred C57BL</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009092" MajorTopicYN="N">Mucous Membrane</DescriptorName>
<QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051560" MajorTopicYN="N">Proto-Oncogene Proteins c-bcl-6</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020123" MajorTopicYN="N">Sirolimus</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020825" MajorTopicYN="N">T-Box Domain Proteins</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016176" MajorTopicYN="N">T-Lymphocyte Subsets</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058570" MajorTopicYN="N">TOR Serine-Threonine Kinases</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year>
<Month>07</Month>
<Day>22</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2017</Year>
<Month>07</Month>
<Day>20</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2017</Year>
<Month>8</Month>
<Day>18</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2017</Year>
<Month>10</Month>
<Day>25</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2017</Year>
<Month>8</Month>
<Day>18</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">28814601</ArticleId>
<ArticleId IdType="pii">jimmunol.1501638</ArticleId>
<ArticleId IdType="doi">10.4049/jimmunol.1501638</ArticleId>
<ArticleId IdType="pmc">PMC5605445</ArticleId>
<ArticleId IdType="mid">NIHMS896111</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>Immunity. 2013 Oct 17;39(4):687-96</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24076049</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Immunol. 2013 Dec;14(12):1294-301</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24162776</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochem Biophys Res Commun. 2003 Oct 31;310(4):1188-93</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14559241</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunity. 2014 Oct 16;41(4):633-45</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25308332</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2002 Apr 1;168(7):3181-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11907070</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Infect Dis. 2014 Nov 1;210(9):1508-16</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24823625</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunity. 2011 Nov 23;35(5):792-805</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22118527</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunity. 2014 Aug 21;41(2):230-43</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25148024</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JCI Insight. 2016 Jul 7;1(10):null</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27468427</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Immunol. 2009 Feb;10 (2):176-84</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19136962</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunity. 2015 Dec 15;43(6):1101-11</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26682984</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2015 Mar 10;10(3):e0120274</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25756182</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunity. 2010 Jan 29;32(1):67-78</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20060330</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Methods Mol Biol. 2012;821:305-16</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22125074</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunity. 2012 Jan 27;36(1):68-78</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22206904</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2009 Jul 15;183(2):1044-54</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19553528</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Exp Med. 2010 Mar 15;207(3):553-64</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20156972</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Protoc. 2014 Jan;9(1):209-22</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24385150</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Invest. 2015 May;125(5):2090-108</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25893604</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunity. 2011 Apr 22;34(4):541-53</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21511183</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Immunol. 2013 Dec;14(12):1285-93</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24162775</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Immunol. 2009 May;10(5):524-30</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19305395</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Immunol. 2014 Aug;15(8):749-757</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24973821</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunity. 2004 May;20(5):551-62</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15142524</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Exp Med. 2011 May 9;208(5):1001-13</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21518797</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2009 Jul 2;460(7251):108-12</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19543266</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):17872-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20923878</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunity. 2012 Mar 23;36(3):374-87</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22425248</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Blood. 2008 Dec 1;112(12):4546-54</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18812469</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Immunol. 2008 May;9(5):513-21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18391955</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Pathog. 2016 Dec 13;12 (12 ):e1006104</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27959961</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Exp Med. 2002 Jun 17;195(12):1541-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12070282</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2006 Feb 15;176(4):2079-83</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16455963</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2002 May 15;168(10):4827-31</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11994430</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Exp Med. 2013 Jun 3;210(6):1189-200</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23712431</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Immunol. 2007 Jun;7(6):454-65</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17525754</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2012 Apr 13;149(2):274-93</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22500797</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunity. 2009 Jul 17;31(1):131-44</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19604492</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunity. 2007 Aug;27(2):281-95</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17723218</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Immunol. 2011 Apr;12(4):295-303</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21358638</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunol Rev. 2006 Jun;211:154-63</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16824125</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2006 Nov 1;177(9):6072-80</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17056533</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2003 Sep 1;171(5):2435-45</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12928391</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mitochondrion. 2007 Dec;7(6):374-85</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17890163</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2014 Oct 3;346(6205):93-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25170048</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2013 Jul 1;191(1):187-99</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23733882</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochem Soc Trans. 2009 Feb;37(Pt 1):217-22</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19143635</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2012 May 1;109(18):7037-42</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22509047</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunity. 2009 Nov 20;31(5):811-22</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19913445</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunity. 2013 Aug 22;39(2):286-97</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23932570</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2010 Nov 1;185(9):5315-25</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20921525</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2011 Jun 15;186(12):6667-71</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21572025</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2005 Feb 18;280(7):5870-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15576369</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Dev Cell. 2010 Apr 20;18(4):592-604</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20412774</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2014 Sep 1;193(5):2067-71</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25070853</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Biol. 2004 Jul 27;14(14):1296-302</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15268862</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2008 Sep 1;181(5):2980-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18713968</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2014 Oct 3;346(6205):98-101</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25170049</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2013 Oct 14;8(10):e77537</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24155966</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Immunol. 2016 Feb;16(2):79-89</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26688350</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Illinois</li>
<li>Nouveau-Mexique</li>
</region>
<settlement><li>Chicago</li>
</settlement>
</list>
<tree><country name="États-Unis"><region name="Illinois"><name sortKey="Sowell, Ryan T" sort="Sowell, Ryan T" uniqKey="Sowell R" first="Ryan T" last="Sowell">Ryan T. Sowell</name>
</region>
<name sortKey="Cao, Yanxia" sort="Cao, Yanxia" uniqKey="Cao Y" first="Yanxia" last="Cao">Yanxia Cao</name>
<name sortKey="Castillo, Eliseo F" sort="Castillo, Eliseo F" uniqKey="Castillo E" first="Eliseo F" last="Castillo">Eliseo F. Castillo</name>
<name sortKey="Finnegan, Alison" sort="Finnegan, Alison" uniqKey="Finnegan A" first="Alison" last="Finnegan">Alison Finnegan</name>
<name sortKey="Finnegan, Alison" sort="Finnegan, Alison" uniqKey="Finnegan A" first="Alison" last="Finnegan">Alison Finnegan</name>
<name sortKey="Goldufsky, Josef W" sort="Goldufsky, Josef W" uniqKey="Goldufsky J" first="Josef W" last="Goldufsky">Josef W. Goldufsky</name>
<name sortKey="Goldufsky, Josef W" sort="Goldufsky, Josef W" uniqKey="Goldufsky J" first="Josef W" last="Goldufsky">Josef W. Goldufsky</name>
<name sortKey="Marzo, Amanda L" sort="Marzo, Amanda L" uniqKey="Marzo A" first="Amanda L" last="Marzo">Amanda L. Marzo</name>
<name sortKey="Marzo, Amanda L" sort="Marzo, Amanda L" uniqKey="Marzo A" first="Amanda L" last="Marzo">Amanda L. Marzo</name>
<name sortKey="Quiles, Zurisaday" sort="Quiles, Zurisaday" uniqKey="Quiles Z" first="Zurisaday" last="Quiles">Zurisaday Quiles</name>
<name sortKey="Rogozinska, Magdalena" sort="Rogozinska, Magdalena" uniqKey="Rogozinska M" first="Magdalena" last="Rogozinska">Magdalena Rogozinska</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Bois/explor/RapamycinFungusV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000822 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000822 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Bois
   |area=    RapamycinFungusV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:28814601
   |texte=   IL-15 Complexes Induce Migration of Resting Memory CD8 T Cells into Mucosal Tissues.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:28814601" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a RapamycinFungusV1

This area was generated with Dilib version V0.6.38.
Data generation: Thu Nov 19 21:55:41 2020. Site generation: Thu Nov 19 22:00:39 2020

	Serveur d'exploration sur la rapamycine et les champignons
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur la rapamycine et les champignons

IL-15 Complexes Induce Migration of Resting Memory CD8 T Cells into Mucosal Tissues.

IL-15 Complexes Induce Migration of Resting Memory CD8 T Cells into Mucosal Tissues.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki